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发布日期:2021年04月14日
MDM2 (IF2) Mouse Monoclonal Antibody
MDM2
MDM2 on dedifferentiated liposarcoma.
MDM2 (IF2) Mouse Monoclonal Antibody

Specialties: Soft Tissue Pathology

Updated: 2020-12-16 08:33:03

Mouse double minute protein 2 (MDM2) is a gene encoded on the 12q13-14 chromosomal sequence.1-5 It encodes for a 483 amino acid residue protein which binds to the amino-terminal transcription region of p53.2,5  MDM2 has been shown to negatively regulate the tumor-suppressor activity of p53 by three mechanisms:  Blocking p53 transcription, binding to p53 causing it to be exported from the nucleus, and accelerating the destruction of p53.1  MDM2 up-regulation has been shown in liposarcoma while being absent in lipoma.2,4 Therefore, anti-MDM2 has been demonstrated to be a potentially useful tool in distinguishing well-differentiated liposarcoma (atypical lipomatous tumor) from lipoma, with the neoplastic cells positive in the former lesion and negative in lipoma.2,4

  1. Uhrinova S, et al. Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding. J Mol Biol. 2005; 350:587-98.
  2. Arici A, et al. Immunohistochemical detection of p53 and MDM2 expressions in liposarcoma with World health organization classification. Indian J Cancer. 2013; 50:164-9.
  3. Ware PL, et al. MDM2 copy numbers in well-differentiated and dedifferentiated liposarcoma: characterizing progression to high-grade tumors. Am J Clin Pathol. 2014; 141:334-41.
  4. Binh MB, et al. Reproducibility of MDM2 and CDK4 staining in soft tissue tumors. Am J Clin Pathol. 2006; 125:693-7.
  5. Momand J, et al. The MDM2 gene amplification database. Nucleic Acids Res. 1998; 26:3453-9.

Specifications


  • Reactivity: paraffin
  • Control: Well-differentiated liposarcoma (Nuclear); Dedifferentiated liposarcoma (Nuclear)
  • Dilution Range: 1:25-1:50 *

Package Inserts


IFU SDS
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Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate479M-94
0.5 mL concentrate479M-95
1.0 mL concentrate479M-96
1.0 mL predilute ready-to-use479M-97
7.0 mL predilute ready-to-use479M-98

For research use only (RUO) in Canada

0.1 mL concentrate (RUO)479M-94-RUO
1.0 mL concentrate (RUO)479M-96-RUO
1.0 mL predilute ready-to-use (RUO)479M-97-RUO
7.0 mL predilute ready-to-use (RUO)479M-98-RUO

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate479M-94
0.5 mL concentrate479M-95
1.0 mL concentrate479M-96
1.0 mL predilute ready-to-use479M-97
7.0 mL predilute ready-to-use479M-98

For research use only (RUO) in Japan

0.1 mL concentrate (RUO)479M-94-RUO
1.0 mL concentrate (RUO)479M-96-RUO
1.0 mL predilute ready-to-use (RUO)479M-97-RUO
7.0 mL predilute ready-to-use (RUO)479M-98-RUO

 

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